Immunohistochemical expression of CD155 in invasive female breast carcinoma and its correlation with tumor infiltrating natural killer cells

Abstract Background CD155 is an immune checkpoint protein that interacts with ligands on natural killer cells to regulate the tumor associated immunity. overexpression has been detected in many human cancer types. and its pathways are promising immunotherapy targets. We aimed evaluate immunohistochemical expression of invasive breast carcinomas correlate such pathological parameters tumors also - infiltrating lymphocytes (NK-TILs) density tissue as highlighted by CD56 immunostaining. This study included 78 cases carcinomas. Immunohistochemistry was performed using antibodies against which a marker for stromal NK cells. Results 30.8% correlated significantly advanced prognostic stage, Estrogen receptor (ER) Progesterone (PR) negativity, high Ki-67 index Human epidermal 2 (HER2) enriched molecular subtype. High TILs 28.2% histologic grade, PR HER2 neu over-expression, index, more aggressive subtypes; triple negative cancer, Luminal B-HER2 positive. Finally, statistically significant direct correlation between Tumor expression. Conclusions Our results support cell cancers rich hormone receptors negative, highlighting those possible candidates targeted therapy.